The effects of certain angioneogenesis inhibitors in experimental endometriosis in rats

A. Barbe; A. Berbets; I. Davydenko; V. Yuzko; O. Yuzko

doi:10.22494/cot.v7i2.101

A. Barbe Bukovinian State Medical University, Chernivtsi, Ukraine
A. Berbets Bukovinian State Medical University, Chernivtsi, Ukraine
I. Davydenko Bukovinian State Medical University, Chernivtsi, Ukraine
V. Yuzko Bukovinian State Medical University, Chernivtsi, Ukraine
O. Yuzko Bukovinian State Medical University, Chernivtsi, Ukraine

DOI: https://doi.org/10.22494/cot.v7i2.101

Keywords: experimental endometriosis, angioneogenesis, VEGF, dopamine agonist, COX-2 inhibitor, cabergoline, celecoxib

Abstract

The pathogenetic theory of retrograde outflow of endometrial cells into the peritoneal cavity at endometriosis is gaining an increasing support. Adequate blood supply and angioneogenesis play an important role in successful implantation and occurrence of ectopic foci. VEGF plays an important role in this process. Determination of the pathways affecting the activity of this factor seems to be promising in terms of its effect produced on the early pathogenetic links of endometriosis.
Objectives: to determine the effectiveness of dopamine agonist cabergoline and highly selective COX-2 inhibitor celecoxib in an experimental model of external genital endometriosis in rats.
Methods. 83 outbred white female rats of Rattus Norvegicus Wistar were involved in the experiment. Experimental induction of endometriosis was performed by surgery and implantation of the autologous uterine fragments. The type and volume of experimental endometriosis lesions on the peritoneum of experimental animals were evaluated macroscopically as well as their hystologic examination were performed.
Results. Administration of a dopamine receptor agonist as a VEGF inhibitor separately was found to produce a pronounced inhibitory effect on ectopic endometrioid formation. However, the use of a dopamine receptor agonist in combination with a highly selective COX-2 inhibitor does not lead to potentiation or summation of their effects. At the same time, the use of COX-2 inhibitor alone has shown significantly lower efficacy than using the dopamine receptor agonist as a VEGF inhibitor.
Conclusion. At experimental endometriosis in rats, dopamine agonists and highly selective COX-2 inhibitors were found to be one of VEGF inhibitors available.

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