Cell therapy in gastroenterology
Abstract
The article highlights the up-to-date literary data about the role of tissue and circulating stem cells in the processes of regeneration and carcinogenesis of gastric mucosa and intestine and development of liver and pancreatic fibrosis. The paper also presents the novel methods of treatment of common gastrointestinal diseases with the use of cell and gene technologies.
References
Denisova TP, Shuldyakov VA, Tyultyaeva LA, et al. Monitoring rasprostranennosti zabolevanij vnutrennih organov na primere patologii pishhevaritel’noj sistemy [Monitoring the incidence of diseases of the internal organs on the example of the pathology of the digestive system]. Saratovskij nauchno-medicinskij zhurnal – Saratov Journal of Medical Scientific. 2011; 4:772-776.
Askarov MB. Multipotent mesenchymal stromal cells from autologous bone marrow accelerate regeneration of refractory gastric ulcers. Eksp. Klin. Gastroenterol. 2008; 4:52-54.
Bessède E, Dubus P, Mégraud F, et al. Helicobacter pylori infection and stem cells at the origin of gastric cancer. Oncogene. 2014. http://www.ncbi.nlm.nih.gov/pubmed/25043305.
Ciccocioppo R, Bernardo ME, Russo ML, et al. Allogeneic hematopoietic stem cell transplantation may restore gluten tolerance in patients with celiac disease. J. Pediatr. Gastroenterol. Nutr. 2013; 56(4):422-427.
https://doi.org/10.1097/MPG.0b013e318276a6a7
PMid:23531481
De Miguel MP, Fuentes-Julián S, Blázquez-Martínez A, et al. Immunosuppressive properties of mesenchymal stem cells: advances and applications. Curr. Mol. Med. 2012; 12(5):574-591.
https://doi.org/10.2174/156652412800619950
PMid:22515979
Deng X, Szabo S, Chen L, et al. New cell therapy using bone marrow-derived stem cells/endothelial progenitor cells to accelerate neovascularization in healing of experimental ulcerative colitis. Curr. Pharm. Des. 2011; 17(16):1643-1651.
https://doi.org/10.2174/138161211796197007
PMid:21548863
Dhama K, Chakraborty S, Mahima MY, et al. Novel and emerging therapies safeguarding health of humans and their companion animals: a review. Pak. J. Biol. Sci. 2013; 16(3):101-111.
https://doi.org/10.3923/pjbs.2013.101.111
PMid:24171271
Hoffmann W. Regeneration of the gastric mucosa and its glands from stem cells. Curr. Med. Chem. 2008; 15(29):3133-3144.
https://doi.org/10.2174/092986708786848587
PMid:19075658
Hommes DW, Duijvestein M, Zelinkova Z, et al. Long-term follow-up of autologous hematopoietic stem cell transplantation for severe refractory Crohn’s disease. J. Crohns Colitis. 2011; 5(6):543-549.
https://doi.org/10.1016/j.crohns.2011.05.004
PMid:22115372
Meng Hong-Bo, Gong Jian, Zhou Bo, et al. Therapeutic effect of human umbilical cord-derived mesenchymal stem cells in rat severe acute pancreatitis. Int. J. Clin. Exp. Pathol. 2013; 6(12): 2703-2712.
PMid:24294357 PMCid:PMC3843251
Ishkitiev N, Yaegaki K, Imai T, et al. Novel management of acute or secondary biliary liver conditions using hepatically-differentiated human dental pulp cells. Tissue Eng. Part A. 2014. http://www.ncbi.nlm.nih.gov/pubmed/25234861.
Kikuchi H, Yagi H, Hasegawa H, et al. Therapeutic potential of transgenic mesenchymal stem cells engineered to mediate anti-high mobility group box 1 activity: targeting of colon cancer. J. Surg. Res. 2014; 190(1):134-143.
https://doi.org/10.1016/j.jss.2014.02.047
PMid:24679698
Kniazev OV, Parfenov AI, Ruchkina IN, et al. New possibilities for overcoming the secondary inefficiency of anti-cytokine therapy in patients with inflammatory bowel diseases. Ter. Arkh. 2013; 85(2):57-60.
PMid:23653941
Komori M, Tsuji S, Tsuji M, et al. Efficiency of bone marrow-derived cells in regeneration of the stomach after induction of ethanol-induced ulcers in rats. J. Gastroenterol. 2005; 40(6):591-599.
https://doi.org/10.1007/s00535-005-1593-0
PMid:16007393
Lanthier N, Rubbia-Brandt L, Spahr L. Liver progenitor cells and therapeutic potential of stem cells in human chronic liver diseases. Acta Gastroenterol Belg. 2013; 76(1):3-9.
PMid:23650775
Leggett CL, Gorospe EC, Lutzke L, et al. A new era: endoscopic tissue transplantation. Curr. Opin. Gastroenterol. 2013; 29(5): 495-500.
https://doi.org/10.1097/MOG.0b013e328363e3fd
PMid:23872488 PMCid:PMC3815665
Li L, Liu S, Xu Y, et al. Human umbilical cord-derived mesenchymal stem cells down regulate inflammatory responses by shifting the Treg/Th17 profile in experimental colitis. Pharmacology. 2013; 92(5): 257-64.
https://doi.org/10.1159/000354883
PMid:24280970
Liao X, Cheng An JY, Zhou QJ, et al. Therapeutic effect of autologous bone marrow-derived liver stem cells transplantation in hepatitis B virus-induced liver cirrhosis. Hepatogastroenterology. 2013; 60(123):406-409.
PMid:23178469
Liu G, Neumeister M, Reichensperger J, et al. Therapeutic potential of human adipose stem cells in a cancer stem cell-like gastric cancer cell model. Int. J. Oncol. 2013; 43(4):1301-1309.
https://doi.org/10.3892/ijo.2013.2039
Nasadyuk C, Sklyarov A. Thymohexin exhibits cytoprotective effect in experimental gastric lesions in rats both through the inhibition of inducible nitric oxide synthase and reduction of oxidative mucosal damage. Regul.Pept. 2013; 180:50-57.
https://doi.org/10.1016/j.regpep.2012.11.004
PMid:23201077
Nasadyuk CM. Stem Cell Therapy In The Treatment Of Inflammatory Bowel Disease. Gastroenterology&Hepatology: Open Access. 2014; 1(1):00006.
Peng SY, Chou CJ, Cheng PJ, et al. Therapeutic potential of amniotic-fluid-derived stem cells on liver fibrosis model in mice. Taiwan J. Obstet. Gynecol. 2014; 53(2):151-157.
https://doi.org/10.1016/j.tjog.2014.04.005
PMid:25017258
Qin T, Liu CJ, Zhang HW, et al. Effect of the IkBα mutant gene delivery to mesenchymal stem cells on rat chronic pancreatitis. Genet Mol Res. 2014; 13(1):371-385.
https://doi.org/10.4238/2014.January.21.5
PMid:24535864
Resnick IB, Barkats C, Shapira MY, et al. Treatment of severe steroid resistant acute GVHD with mesenchymal stromal cells (MSC). Am. J. Blood Res. 2013; 19(3):225-238.
Senju S, Koba C, Haruta M, et al. Application of iPS cell-derived macrophages to cancer therapy. Oncoimmunology. 2014; 1(3):e27927.
https://doi.org/10.4161/onci.27927
PMid:24800175 PMCid:PMC4008454
Tarnawski AS, Ahluwalia A. Molecular mechanisms of epithelial regeneration and neovascularization during healing of gastric and esophageal ulcers. Curr. Med. Chem. 2012; 19(1):16-27.
https://doi.org/10.2174/092986712803414088
PMid:22300072
Tarnawski AS. Cellular and molecular mechanisms of gastrointestinal ulcer healing. Dig Dis Sci. 2005; 50(1):S24-33.
https://doi.org/10.1007/s10620-005-2803-6
PMid:16184417
Vacanti JP, Kulig KM. Liver cell therapy and tissue engineering for transplantation. Semin. Pediatr. Surg. 2014; 23(3):150-155.
https://doi.org/10.1053/j.sempedsurg.2014.05.001
PMid:24994529
Vainshtein JM, Kabarriti R, Mehta KJ, et al. Bone marrow-derived stromal cell therapy in cirrhosis: clinical evidence, cellular mechanisms, and implications for the treatment of hepatocellular carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 2014; 15(89):786-803.
https://doi.org/10.1016/j.ijrobp.2014.02.017
PMid:24969793 PMCid:PMC4074358
van Deen W K, Oikonomopoulos A, Hommes DW. Stem cell therapy in inflammatory bowel disease: which, when and how? Curr. Opin. Gastroenterol. 2013; 29(4):384-390.
https://doi.org/10.1097/MOG.0b013e328361f763
PMid:23666365
Varon C, Dubus P, Mazurie F, et al. Helicobacter pylori infection recruits bone marrow-derived cells that participate in gastric preneoplasia in mice. Gastroenterology. 2012; 142(2):281-291.
https://doi.org/10.1053/j.gastro.2011.10.036
PMid:22062361
Voswinkel J, Francois S, Gorin NC, et al. Gastro-intestinal autoimmunity: preclinical experiences and successful therapy of fistulizing bowel diseases and gut Graft versus host disease by mesenchymal stromal cells. Immunol. Res. 2013; 56(2-3):241-248.
https://doi.org/10.1007/s12026-013-8397-8
PMid:23564182
Wan Z, You S, Rong Y, et al. CD34+ hematopoietic stem cells mobilization, paralleled with multiple cytokines elevated in patients with HBV-related acute-on-chronic liver failure. Dig Dis Sci. 2013; 58(2):448-457.
https://doi.org/10.1007/s10620-012-2458-z
PMid:23095991
Watanabe S, Arimura Y, Nagaishi K, et al. Conditioned mesenchymal stem cells produce pleiotropic gut trophic factors. J. Gastroenterol. 2014; 49(2):270-282.
https://doi.org/10.1007/s00535-013-0901-3
PMid:24217964
Yu L, Yang L, An W, et al. Anticancer bioactive peptide-3 inhibits human gastric cancer growth by suppressing gastric cancer stem cells. J. Cell Biochem. 2014; 115(4):697-711.
https://doi.org/10.1002/jcb.24711
PMid:24214799
Zhang Z, Lin H, Shi M, et al. Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients. J. Gastroenterol. Hepatol. 2012; 27(2):112-120.
https://doi.org/10.1111/j.1440-1746.2011.07024.x
PMid:22320928