Cell therapy in gastroenterology

  • C. Nasadyuk Danylo Halitsky Lviv National Medical University, Lviv, Ukraine
Keywords: stem cells, regenerative therapy, gastrointestinal tract

Abstract

The article highlights the up-to-date literary data about the role of tissue and circulating stem cells in the processes of regeneration and carcinogenesis of gastric mucosa and intestine and development of liver and pancreatic fibrosis. The paper also presents the novel methods of treatment of common gastrointestinal diseases with the use of cell and gene technologies.

References

Denisova TP, Shuldyakov VA, Tyultyaeva LA, et al. Monitoring rasprostranennosti zabolevanij vnutrennih organov na primere patologii pishhevaritel’noj sistemy [Monitoring the incidence of diseases of the internal organs on the example of the pathology of the digestive system]. Saratovskij nauchno-medicinskij zhurnal – Saratov Journal of Medical Scientific. 2011; 4:772-776.

Askarov MB. Multipotent mesenchymal stromal cells from autologous bone marrow accelerate regeneration of refractory gastric ulcers. Eksp. Klin. Gastroenterol. 2008; 4:52-54.

Bessède E, Dubus P, Mégraud F, et al. Helicobacter pylori infection and stem cells at the origin of gastric cancer. Oncogene. 2014. http://www.ncbi.nlm.nih.gov/pubmed/25043305.

Ciccocioppo R, Bernardo ME, Russo ML, et al. Allogeneic hematopoietic stem cell transplantation may restore gluten tolerance in patients with celiac disease. J. Pediatr. Gastroenterol. Nutr. 2013; 56(4):422-427.

https://doi.org/10.1097/MPG.0b013e318276a6a7

PMid:23531481

De Miguel MP, Fuentes-Julián S, Blázquez-Martínez A, et al. Immunosuppressive properties of mesenchymal stem cells: advances and applications. Curr. Mol. Med. 2012; 12(5):574-591.

https://doi.org/10.2174/156652412800619950

PMid:22515979

Deng X, Szabo S, Chen L, et al. New cell therapy using bone marrow-derived stem cells/endothelial progenitor cells to accelerate neovascularization in healing of experimental ulcerative colitis. Curr. Pharm. Des. 2011; 17(16):1643-1651.

https://doi.org/10.2174/138161211796197007

PMid:21548863

Dhama K, Chakraborty S, Mahima MY, et al. Novel and emerging therapies safeguarding health of humans and their companion animals: a review. Pak. J. Biol. Sci. 2013; 16(3):101-111.

https://doi.org/10.3923/pjbs.2013.101.111

PMid:24171271

Hoffmann W. Regeneration of the gastric mucosa and its glands from stem cells. Curr. Med. Chem. 2008; 15(29):3133-3144.

https://doi.org/10.2174/092986708786848587

PMid:19075658

Hommes DW, Duijvestein M, Zelinkova Z, et al. Long-term follow-up of autologous hematopoietic stem cell transplantation for severe refractory Crohn’s disease. J. Crohns Colitis. 2011; 5(6):543-549.

https://doi.org/10.1016/j.crohns.2011.05.004

PMid:22115372

Meng Hong-Bo, Gong Jian, Zhou Bo, et al. Therapeutic effect of human umbilical cord-derived mesenchymal stem cells in rat severe acute pancreatitis. Int. J. Clin. Exp. Pathol. 2013; 6(12): 2703-2712.

PMid:24294357 PMCid:PMC3843251

Ishkitiev N, Yaegaki K, Imai T, et al. Novel management of acute or secondary biliary liver conditions using hepatically-differentiated human dental pulp cells. Tissue Eng. Part A. 2014. http://www.ncbi.nlm.nih.gov/pubmed/25234861.

Kikuchi H, Yagi H, Hasegawa H, et al. Therapeutic potential of transgenic mesenchymal stem cells engineered to mediate anti-high mobility group box 1 activity: targeting of colon cancer. J. Surg. Res. 2014; 190(1):134-143.

https://doi.org/10.1016/j.jss.2014.02.047

PMid:24679698

Kniazev OV, Parfenov AI, Ruchkina IN, et al. New possibilities for overcoming the secondary inefficiency of anti-cytokine therapy in patients with inflammatory bowel diseases. Ter. Arkh. 2013; 85(2):57-60.

PMid:23653941

Komori M, Tsuji S, Tsuji M, et al. Efficiency of bone marrow-derived cells in regeneration of the stomach after induction of ethanol-induced ulcers in rats. J. Gastroenterol. 2005; 40(6):591-599.

https://doi.org/10.1007/s00535-005-1593-0

PMid:16007393

Lanthier N, Rubbia-Brandt L, Spahr L. Liver progenitor cells and therapeutic potential of stem cells in human chronic liver diseases. Acta Gastroenterol Belg. 2013; 76(1):3-9.

PMid:23650775

Leggett CL, Gorospe EC, Lutzke L, et al. A new era: endoscopic tissue transplantation. Curr. Opin. Gastroenterol. 2013; 29(5): 495-500.

https://doi.org/10.1097/MOG.0b013e328363e3fd

PMid:23872488 PMCid:PMC3815665

Li L, Liu S, Xu Y, et al. Human umbilical cord-derived mesenchymal stem cells down regulate inflammatory responses by shifting the Treg/Th17 profile in experimental colitis. Pharmacology. 2013; 92(5): 257-64.

https://doi.org/10.1159/000354883

PMid:24280970

Liao X, Cheng An JY, Zhou QJ, et al. Therapeutic effect of autologous bone marrow-derived liver stem cells transplantation in hepatitis B virus-induced liver cirrhosis. Hepatogastroenterology. 2013; 60(123):406-409.

PMid:23178469

Liu G, Neumeister M, Reichensperger J, et al. Therapeutic potential of human adipose stem cells in a cancer stem cell-like gastric cancer cell model. Int. J. Oncol. 2013; 43(4):1301-1309.

https://doi.org/10.3892/ijo.2013.2039

Nasadyuk C, Sklyarov A. Thymohexin exhibits cytoprotective effect in experimental gastric lesions in rats both through the inhibition of inducible nitric oxide synthase and reduction of oxidative mucosal damage. Regul.Pept. 2013; 180:50-57.

https://doi.org/10.1016/j.regpep.2012.11.004

PMid:23201077

Nasadyuk CM. Stem Cell Therapy In The Treatment Of Inflammatory Bowel Disease. Gastroenterology&Hepatology: Open Access. 2014; 1(1):00006.

Peng SY, Chou CJ, Cheng PJ, et al. Therapeutic potential of amniotic-fluid-derived stem cells on liver fibrosis model in mice. Taiwan J. Obstet. Gynecol. 2014; 53(2):151-157.

https://doi.org/10.1016/j.tjog.2014.04.005

PMid:25017258

Qin T, Liu CJ, Zhang HW, et al. Effect of the IkBα mutant gene delivery to mesenchymal stem cells on rat chronic pancreatitis. Genet Mol Res. 2014; 13(1):371-385.

https://doi.org/10.4238/2014.January.21.5

PMid:24535864

Resnick IB, Barkats C, Shapira MY, et al. Treatment of severe steroid resistant acute GVHD with mesenchymal stromal cells (MSC). Am. J. Blood Res. 2013; 19(3):225-238.

Senju S, Koba C, Haruta M, et al. Application of iPS cell-derived macrophages to cancer therapy. Oncoimmunology. 2014; 1(3):e27927.

https://doi.org/10.4161/onci.27927

PMid:24800175 PMCid:PMC4008454

Tarnawski AS, Ahluwalia A. Molecular mechanisms of epithelial regeneration and neovascularization during healing of gastric and esophageal ulcers. Curr. Med. Chem. 2012; 19(1):16-27.

https://doi.org/10.2174/092986712803414088

PMid:22300072

Tarnawski AS. Cellular and molecular mechanisms of gastrointestinal ulcer healing. Dig Dis Sci. 2005; 50(1):S24-33.

https://doi.org/10.1007/s10620-005-2803-6

PMid:16184417

Vacanti JP, Kulig KM. Liver cell therapy and tissue engineering for transplantation. Semin. Pediatr. Surg. 2014; 23(3):150-155.

https://doi.org/10.1053/j.sempedsurg.2014.05.001

PMid:24994529

Vainshtein JM, Kabarriti R, Mehta KJ, et al. Bone marrow-derived stromal cell therapy in cirrhosis: clinical evidence, cellular mechanisms, and implications for the treatment of hepatocellular carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 2014; 15(89):786-803.

https://doi.org/10.1016/j.ijrobp.2014.02.017

PMid:24969793 PMCid:PMC4074358

van Deen W K, Oikonomopoulos A, Hommes DW. Stem cell therapy in inflammatory bowel disease: which, when and how? Curr. Opin. Gastroenterol. 2013; 29(4):384-390.

https://doi.org/10.1097/MOG.0b013e328361f763

PMid:23666365

Varon C, Dubus P, Mazurie F, et al. Helicobacter pylori infection recruits bone marrow-derived cells that participate in gastric preneoplasia in mice. Gastroenterology. 2012; 142(2):281-291.

https://doi.org/10.1053/j.gastro.2011.10.036

PMid:22062361

Voswinkel J, Francois S, Gorin NC, et al. Gastro-intestinal autoimmunity: preclinical experiences and successful therapy of fistulizing bowel diseases and gut Graft versus host disease by mesenchymal stromal cells. Immunol. Res. 2013; 56(2-3):241-248.

https://doi.org/10.1007/s12026-013-8397-8

PMid:23564182

Wan Z, You S, Rong Y, et al. CD34+ hematopoietic stem cells mobilization, paralleled with multiple cytokines elevated in patients with HBV-related acute-on-chronic liver failure. Dig Dis Sci. 2013; 58(2):448-457.

https://doi.org/10.1007/s10620-012-2458-z

PMid:23095991

Watanabe S, Arimura Y, Nagaishi K, et al. Conditioned mesenchymal stem cells produce pleiotropic gut trophic factors. J. Gastroenterol. 2014; 49(2):270-282.

https://doi.org/10.1007/s00535-013-0901-3

PMid:24217964

Yu L, Yang L, An W, et al. Anticancer bioactive peptide-3 inhibits human gastric cancer growth by suppressing gastric cancer stem cells. J. Cell Biochem. 2014; 115(4):697-711.

https://doi.org/10.1002/jcb.24711

PMid:24214799

Zhang Z, Lin H, Shi M, et al. Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients. J. Gastroenterol. Hepatol. 2012; 27(2):112-120.

https://doi.org/10.1111/j.1440-1746.2011.07024.x

PMid:22320928

Published
2015-05-31
How to Cite
1.
Nasadyuk C. Cell therapy in gastroenterology. JCOT [Internet]. 31May2015 [cited 7Oct.2026];3(1):78-1. Available from: https://jcot.transplantology.org/index.php?journal=jcot&page=article&op=view&path[]=2015-3-1_7